Leighton R. James, M.D.
Assistant Professor of Internal Medicine

	High glucose and glucosamine increase O-glycosylation of p65/Rel A NF-kB subunit.

Research Interests:

Diabetic kidney disease, gene-targeting, hexosamine pathway, mouse models of kidney and cardiovascular disease, mesangial cell pathophysiology

Selected Publications:

Caron KM, James LR, Kim HS, Morham SG, Sequeira Lopez ML, Gomez RA, Reudelhuber TL, Smithies O. A genetically clamped renin transgene for the induction of hypertension. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8248-52.

James LR, Tang D, Ingram A, Ly H, Thai K, Cai L, Scholey JW. Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation. Diabetes. 2002 Apr;51(4):1146-56.

Krepinsky J, Ingram AJ, James L, Ly H, Thai K, Cattran DC, Miller JA, Scholey JW. 17beta -Estradiol modulates mechanical strain-induced MAPK activation in mesangial cells. J Biol Chem. 2002 Mar 15;277(11):9387-94.

James LR, Ingram A, Ly H, Thai K, Cai L, Scholey JW. Angiotensin II activates the GFAT promoter in mesangial cells. Am J Physiol Renal Physiol. 2001 Jul;281(1):F151-62.

James LR, Fantus IG, Goldberg H, Ly H, Scholey JW. Overexpression of GFAT activates PAI-1 promoter in mesangial cells. Am J Physiol Renal Physiol. 2000 Oct;279(4):F718-27.

Ingram AJ, James L, Ly H, Thai K, Scholey JW. Stretch activation of jun N-terminal kinase/stress-activated protein kinase in mesangial cells. Kidney Int. 2000 Oct;58(4):1431-9.

Ingram AJ, James L, Cai L, Thai K, Ly H, Scholey JW. NO inhibits stretch-induced MAPK activity by cytoskeletal disruption. J Biol Chem. 2000 Dec 22;275(51):40301-6.

Ingram AJ, James L, Ly H, Thai K, Cai L, Scholey JW. Nitric oxide modulates stretch activation of mitogen-activated protein kinases in mesangial cells. Kidney Int. 2000 Sep;58(3):1067-77.

Ingram AJ, James L, Thai K, Ly H, Cai L, Scholey JW. Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells. Am J Physiol Renal Physiol. 2000 Aug;279(2):F243-51.

James LR, Lajoie G, Prajapati D, Gan BS, Bargman JM. Calciphylaxis precipitated by ultraviolet light in a patient with end-stage renal disease secondary to systemic lupus erythematosus. Am J Kidney Dis. 1999 Nov;34(5):932-6.