Khashayar Sakhaee, M.D.
Professor of Internal Medicine
Chief, Division of Mineral Metabolism
GCRC Program Director
Elucidation of the pathophysiological basis of uric acid and calcium nephrolithiasis, study of regulation of renal citrate excretion in patients with calcium nephrolithiasis; pathophysiological roles of acidosis on skeletal bone metabolism in elderly patients and patients with CKD, patients with distal renal tubular acidosis and their management with oral alkali treatment, pathogenesis and treatment of osteoporosis, and study of skeletal abnormalities in patients with chronic renal failure.
Selected Publications:
Pak CY, Sakhaee K, Moe O, Preminger GM, Poindexter JR, Peterson RD, Pietrow P, Ekeruo W. Biochemical profile of stone-forming patients with diabetes mellitus. Urology. 2003 Mar;61(3):523-7.
Moe OW, Abate N, Sakhaee K. Pathophysiology of uric acid nephrolithiasis. Endocrinol Metab Clin North Am. 2002 Dec;31(4):895-914.
Heller HJ, Sakhaee K, Moe OW, Pak CY. Etiological role of estrogen status in renal stone formation. J Urol. 2002 Nov;168(5):1923-7.
Sakhaee K, Adams-Huet B, Moe OW, Pak CY. Pathophysiologic basis for normouricosuric uric acid nephrolithiasis. Kidney Int. 2002 Sep;62(3):971-9.
Reddy ST, Wang CY, Sakhaee K, Brinkley L, Pak CY. Effect of low-carbohydrate high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolism. Am J Kidney Dis. 2002 Aug;40(2):265-74.
Pak CY, Sakhaee K, Peterson RD, Poindexter JR, Frawley WH. Biochemical profile of idiopathic uric acid nephrolithiasis. Kidney Int. 2001 Aug;60(2):757-61.
Sakhaee K. Is there an optimal parathyroid hormone level in end-stage renal failure: the lower the better? Curr Opin Nephrol Hypertens. 2001;10(3):421-7.
Sakhaee K, Gonzalez GB. Update on renal osteodystrophy: pathogenesis and clinical management. Am J Med Sci. 1999 Apr;317(4):251-60.
Alpern RJ, Sakhaee K. The clinical spectrum of chronic metabolic acidosis: homeostatic mechanisms produce significant morbidity.Am J Kidney Dis. 1997 Feb;29(2):291-302.
