Neuroscience Graduate Program

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A cultured neuron (green) decorated with a post-synaptic marker (red) OverviewNeurobiology is a field defined, not by a specific intellectual approach or experimental technique, but by its subject matter: the cells of the nervous, sensory, and muscular systems. Because of the variety of methods that must be brought to bear in the studies of these systems, the optimal training for a career in neurobiological research includes an in-depth exposure to the principles of biochemistry, biophysics, cell and molecular biology, developmental biology, genetics, immunology, pharmacology, and physiology. By providing a background in these areas, the First Year Curriculum offers appropriate training for students who elect to join the Neuroscience Program.

The research of the faculty of the Neuroscience Program focuses on cellular and molecular neurobiology, and behavioral neuroscience. Topics of particular interest include: membrane biophysics, especially the operation and modulation of ion channels; neuronal organelle traffic, particularly the synthesis, axonal transport, and release of synaptic and secretory vesicles; developmental neurobiology; neurogenetics of invertebrates and vertebrates; and the molecular and cellular basis of complex behavior.

After successfully completing the DBS Core Course , a student selects a mentor and commences dissertation research. Students are expected to participate in the Neuroscience Journal Club, which provides the opportunity to keep abreast of recent research results, sharpen critical acumen, and develop speaking skills. The Neuroscience Program offers a series of advanced graduate seminar courses, designed not only to provide knowledge about a given topic, but also to confer a detailed understanding of experimental procedures and to promote clear presentation of ideas and arguments. Course topics include developmental neurogenetics, neurotransmission, molecular motors, ion-channel modulation, sensory maps, genetic neurological diseases, memory and long-term potentiation, neuronal circuits and behavior, and the neuronal cytoskeleton.

For more information on the Neuroscience Graduate Program, please contact Kasey Thompson, Program Assistant, at (214) 648-1802, or refer to the Southwestern Graduate School of Biomedical Sciences Catalog

Faculty

Program Chair: Jane E. Johnson

Joseph P. Albanesi -- Motility and signaling in neurosecretory systems.

Leon Avery -- Neurogeneics of Caenorhabditis elegans.

Ilya B. Bezprozvanny -- Calcium channels and calcium signaling in the nervous system; deranged calcium signaling and neurodegeneration in Huntington's and Alzheimer's disease.

James A. Bibb -- Signal transduction in the nervous system, with emphasis on the biochemistry and neuropharmacology of protein phosphorylation/dephosphorylation.

Stephen Cannon -- How ion channels regulate electrical excitability of cells and of how defects in these channels lead to human disease.

Donald Cooper -- Behavioral and neurophysiological plasticity within the brain reward circuit and its relationship to addiction.

Christopher Cowan -- Molecular mechanisms of axon guidance and synapse formation/remodeling.

Joel Elmquist -- Functional neuroanatomy of the mammalian hypothalamus.

Jay Gibson -- The electrophysiology of rodent sensory neocortex: cellular, synaptic and systems properties.

Matthew S. Goldberg -- Molecular mechanisms of inherited forms of Parkinson’s disease.

Robert W. Greene -- Control and function of sleep/wake states; system mechanisms of NMDA hypofunction-related cognitive defects.

Mark Henkemeyer -- Molecular biology of axon guidance.

Robin Hiesinger -- Neurogenetics; brain wiring/synaptic specification; synapse function/neurotransmitter release membrane fusion; computational approaches to 4D visualization and simulation.

Donald W. Hilgemann -- Function and regulation of membrane transporters; electrophysiology; biophysics of ion pumps and channels.

Jenny Hsieh -- Stem cell biology; neurogenesis and gliogenesis in CNS; chromatin remodeling; neurological diseases.

Kimberly M. Huber -- Physiology and cellular mechanisms of synaptic plasticity.

Jane E. Johnson -- Molecular biology of mammalian neural development.

Rolf H. Joho -- Molecular and cellular neurobiology; structure/function studies of ion channel proteins.

Ege T. Kavalali -- Physiology and development of central nervous system presynaptic terminals.

Helmut J. Krämer -- Genetic dissection of endocytic trafficking in Drosophila.

Shuxin Li -- Axonal regeneration in the central nervous system; cell death and neuronal survival; spinal cord injury.

Weichun Lin -- Developmental neurobiology.

Qing Richard Lu -- Differentiation mechanisms in the mammalian central nervous system: gliogenesis as a model.

Colleen McClung -- Molecular mechanisms of mood disorders and drug addiction.

Eric Nestler -- Molecular mechanisms of drug addiction and depression.

Luis F. Parada -- The role of proto-oncogenes in vertebrate development; trk receptors and neurotropins.

Juan Pascual -- Animal and cellular models of neurogenetic disorders. Synaptic transmission in experimental epilepsies. Disorders of brain energy metabolism. Developmental neurobiology. Genotype:phenotype correlations in novel childhood encephalopathies. Clinical pediatric neurology.

Andrew Pieper --

Craig Powell -- Molecular and cellular mechanisms of cognition with an emphasis on learning and memory.

José Rizo-Rey (Josep Rizo) -- Structural analysis by nuclear magnetic resonance of proteins involved in calcium-triggered synaptic vesicle exocytosis.

Adrian Rothenfluh - Genetics and neurobiology of behavioral responses to drugs of abuse in the fruit fly.

David W. Self -- Neurobiology of motivational systems and drug addiction.

Dean P. Smith -- Molecular biology of sensory transduction in Drosophila.

Thomas C. Südhof -- Molecular basis of neurotransmitter release and synapse formation.

Carol Tamminga -- Schizophrenia; postmortem brain; human brain imaging; human translational neuroscience.

Malu (Lourdes) Tansey -- Role of TNF and neuroinflammation in neurodegenerative diseases; neural progenitors in adult tissues.

Jonathan Terman -- Axonal growth and guidance; neuronal connectivity; axonal regeneration.

Masashi Yanagisawa -- Identification and characterization of new neuropeptides that regulate vital functions such as sleep, appetite and blood pressure.

Gang G. Yu -- Molecular mechanisms of Alzheimer’s disease and neuronal signaling.